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Although clinical trials specifically for MASH have not yet been conducted, preclinical studies confirm significant regulatory effects on hepatic metabolism, providing a novel strategy for targeted MASH therapy and supporting future translational research

The loss or reduced function of both proteins leads to mitochondrial damage

Diabetic Neuropathy: Helps manage early nerve damage in diabetic patients before it gets worse

They may arrange blood tests to evaluate: Inflammatory markers (ESR, CRP) to detect active inflammation Rheumatoid factor and anti-CCP antibodies if inflammatory arthritis is suspected Full blood count to assess haematological response to B12 treatment Thyroid function tests , as thyroid disorders commonly coexist with B12 deficiency Note that serum B12 levels are not typically measured to assess treatment adequacy once replacement therapy has begun, as they may not reliably reflect tissue stores