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Angiogenesis & Vascular Remodeling Both peptides have documented pro-angiogenic activity BPC-157 via VEGFR2 upregulation, TB-500 via endothelial cell migration and capillary network organization making the stack a focused tool for vascular research
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The candidate eventually selected for further development, peptide 40, which demonstrated exceptional chemical stability, was identical to peptide 12 except for a modification at position 14 by insertion of adipic acid and the aforementioned replacement of the disulfide bridge with a lactam bridge (Tables and S1)
