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Since there is no FDA-approved GHK-Cu drug, responsible physicians inform patients about the uncertain evidence

Abbreviations P11-4: Self-assembling peptide RADA 16: Self-assembling synthetic peptide DPSC: Dentin-derived pulp stem cells Cemp1-P4: Carboxy-Terminal Cementum Protein 1-Derived Peptide 4 Alp: Alkaline phosphatase hMSCs: Human mesenchymal stem cells IL-6: Interleukin-6 GM-15: Synthetic short peptide PCR: C-reactive Protein MTT: 3-[4,5-Dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide KB TUMOR CELLS: KERATIN-forming tumor cell line DJK-5: D-enantiomeric cationic peptide CHX: Chlorhexidine CEMP1-p4: Arboxy-Terminal Cementum Protein 1-Derived Peptide 4 ( HOMSCs: Human Oral Mucosa Stem Cells Runx: Runt-related transcription factor 1 CPC: Cetylpyridinium chloride RT-PCR: Real time pcr SEM: Scanning electron microscopy FBS: Fetal bovine serum OSCC CELLS: Oral squamous cell carcinoma SCC15 CELLS: Squamous cell carcinoma cell lines CAL27 CELLS: Squamous cell carcinoma cell lines PEP-B: Pathogen elicitor peptide LDH: Lactate Dehydrogenase LPS: Lipopolysaccharide hDPSCs: Human dental pulp stem cells ROS: Reactive oxygen species' NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells MAPK: Mitogen-activated protein kinase PGR: Plant growth regulators HGFs: Ematopoietic growth factors Quadas-2: Quality Assessment of Diagnostic Accuracy Studies CsA: Ciclosporine A AEDG: Arachidonic acid -Eicosanoids-Diacylglycerol-Glycerophosphoinositol KED: Kinase-Dependent pathway Cal27 cells: Oral squamous cell carcinoma lines (CPPs): Cell-penetrating peptides References Antony P, Vijayan R