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Interestingly, APOE4 also modulates the effect of switching from a high-fat diet to a low-fat diet on plasma cholesterol levels: APOE4 carriers who switched from a high-fat diet to low fat and low glycemic index high carb diet had greater reductions in LDL-C (Griffin et al., Older APOE4 carriers with CI also show resistance to improvement from a ketogenic diet

Future should aim to investigate these complex mechanisms, develop precise therapeutic methods, and advance personalized medicine and emerging fields, such as gut microbiota research to enhance treatment outcomes