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doi:10.1146/annurev.nu.05.070185.000555
Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal, further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly (for parenteral supplementation) or daily (for oral supplementation)
In contrast, 10 studies investigated the relationship between B12 supplementation status and homocysteine levels, encompassing a total of 191 participants (mean: 19.1 per study)
doi: 10.1021/jm7013887
