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This leads to estrogen dominance (often causing weight gain in the thighs and abdomen, as well as cellulite) and inhibits the bodys ability to properly produce T4 thyroid hormone, leading to poor production of the active thyroid hormone (T3)

Transcriptional regulation by Nrf2

However, LA increased hepatic cholesterol and reduced LDL receptor protein conversion regulatory factors compared with the model group despite reduced mRNA expression of hepatic cholesterol synthesis enzyme (HMG-CoAr) and blood levels of cholesterol and LDL

[DOI] [Google Scholar] Leng X., Wu X., Tian J., Li X., Guan L., Weng D