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For some substances, it is important to think of the human or animal body as being made up of several parts, each with its own affinity for the substance, and each part with a different biological half-life (physiologically-based pharmacokinetic modelling)

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Thermodynamic aspects of free radical reactions As discussed above, one of the major reasons why low-molecular-weight antioxidants do not provide sufficient protection of biomolecules against ROS is that biomolecules react faster with ROS than do antioxidants (Jomova and Valko 2011)

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