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This small, membrane-permeable molecule with chemical formula C10H11N2+ works by improving glucose clearance from the blood and enabling cells to more rapidly use available energy

Similarly, fisetin, a flavonoid found in strawberries and other fruits, activates SIRT1 by increasing NAD + levels while also reducing oxidative stress and inflammation 179 (Fig

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Patients with diagnosed diabetes should monitor glucose closely, as MOTS-cs insulin-sensitizing effects may potentiate hypoglycemia when combined with antidiabetic medications