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Mild, transient fluid retention/edema and joint or muscle pain, each reported more often on MK-677 than placebo in the same trial, linked to elevated GH and IGF-1

10.1016/j.ijbiomac.2022.09.123 121 WangQ.ChenH.YinM.ChengX.XiaH.HuH.et al (2023a)
Differential expression of metallothioneins (MTs) 1, 2, and 3 in response to zinc treatment in human prostate normal and malignant cells and tissues

The SAM-dependent protein methyltransferase encoded by the LCMT1 gene (leucine carboxyl methyltransferase 1) catalyzes the methylation of a C-terminal leucine residue in the Ser/Thr phosphatase identified as PP2A, a modification required for its proper function
