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CONCLUSION While the development of antiobesity drugs continues to look challenging, researchers retain the hope that effective and safe medications might be on the horizon

Zhang L, Fan J, Li G, Yin Z, Fu BM
The CBS upregulation hypothesis and thats all it was has been discredited for at least 8-10 years

2013), the vast majority of potential Nrf2 modulators are electrophiles with an inherent propensity to interact with off-target cellular nucleophiles
