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When AML primary cells, cell lines, and normal CD34 hematopoietic cells were cultured in the medium with or without glutamine, lack of glutamine inhibited the proliferation and survival of AML cells but had no significant inhibitory effects on CD34 hematopoietic cells

Ferroptosis has been widely observed in small-molecule treated cells in vitro, and was implicated in various pathological conditions including neurodegeneration, ischemia/reperfusion-induced kidney, heart and liver injury, and stroke 2

In CLL, leukemia progression consists of recirculation of cancer cells from the blood to the lymphoid organs, and this process is coordinated by the chemokine CXCL12 and its receptor CXCR4 [31]