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ARISTADA is a prodrug of aripiprazole and its activity is primarily due to aripiprazole, and to a lesser extent dehydro-aripiprazole (major metabolite of aripiprazole), which has been shown to have affinities for D2 receptors similar to aripiprazole and represents 30-40% of the aripiprazole exposure in plasma

Natural history of ovarian function including assessment of ovarian reserve and premature ovarian failure

The mitochondrial proteins that are targets of GAPDH-mediated transnitrosylation are involved in the regulation of mitochondrial membrane permeability that includes voltage-dependent anion channel 1 (VDAC1)

This affects the activation and proliferation of T-cells and suggests that pericytes shape the functions of T-cells during their transmigration into the CNS after antigen-specific interaction (125) ( Figure 3 )