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Those with absorption challenges

This is the most popular ratio because the numbers work out cleanly

Many patients pair this with GLP-1s, hormone therapy, or wellness programs to enhance results
There is also some limited evidence suggesting that individuals who carry certain polymorphisms in genes involved in vitamin C transport and detoxification mechanisms may have lower plasma vitamin C concentrations even with high vitamin C intakes (see also Vascular complications of diabetes mellitus) (reviewed in 27)
