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These antioxidant enzymes include GSTs, catalases, superoxide dismutases, thioredoxins, glutathione peroxidases, glutaredoxins and thioredoxin peroxidases 52 , 53 (Figure 2)
Therefore, GSH depletion by GPX4 reduces LOOH (e.g., PE-AA-OOH) to nontoxic lipid alcohols (LOH, e.g., PE-AA-OH) (Yang et al
Previous studies suggested that GLP-1 diabetes and weight loss drugs, such as semaglutide (brand name Wegovy or Ozempic), could worsen diabetic retinopathy and associated conditions
However, this is an intermediate process, not the final result, and the mechanism behind the final cell death is still unclear
