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This implies that systemic administration of such agents could inadvertently suppress antitumor immunity, canceling out the benefits of ROS-induced tumor killing
The enhanced expression of IFN by Th1 cells in the absence of eosinophils was not only seen in the scRNA-seq ( Figure 6D ), but was also corroborated by RT-qPCR analysis ( Figure 6E ) and by intracellular IFN staining of CD11b - CD3 + CD4 + cells ( Figure 6F ) performed with total skin cell lysates or cell suspensions, respectively
Moreover, studies have shown that cannabidivarin has a promising ability to alleviate behavioral alterations, and clinical trials with this compound have exhibited notable enhancements in individuals with autism [111]
Taken together, the Nori case may represent a rapid, memory T-celldriven model, whereas ICI-associated cases (including that reported by Gianni et al
