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For instance, in Oreochromis mossambicus (tilapia), both laboratory and field studies in the Chicamba reservoir of Revue river system, Mozambique, showed that elevated Hg levels induced MT overexpression in hepatic tissues, establishing a strong correlation between Hg exposure and MT expression (Monjane-Mabuie et al., 2022)

Clinically, high MT2A expression correlated with advanced tumor stages and poor survival across TCGA cohorts