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Subsequently, iron is released from transferrin and undergoes reduction to its divalent form by lysosomal reductases before being transported into the cytosol via divalent metal transporter 1 (DMT1) and transient receptor potential mucolipin (TRPML1/2), ultimately entering the cellular labile iron pool (LIP) [97]

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The cell uses different antioxidant defenses, including superoxide dismutase, catalase, glutathione detoxification pathways, and thioredoxin detoxification pathways (Kudin et al., 2012)

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