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Parra, M., Stahl, S., & Hellmann, H

The abnormal release of Ca 2+ from the mitochondria to the cytosol leads to the activation of microglia, neuroinflammation, and finally, cell death [29, 93]

Effects of prebiotics and phytochemicals on serum trimethylamine N-oxide reduction and gut microbiota: a systematic review and meta-analysis

This is coupled with an exaggerated inflammatory response driven by the intestinal microbiota, leading to extensive infiltration of various immune cells, including T cells, B cells, dendritic cells (DCs), macrophages, and neutrophils, into the lamina propria