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The skin lightening market is worth an estimated R130 billion, and despite the many health risks associated with the practice, this number is expected to reach approximately R300 billion by the year 2020, according to a 2009 Global Industry Analysts report

Another cause - granted, identified as rare - is a B12 deficiency

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Moreover, novel bivalent and hybrid curcumin compounds show superior membrane integration and multipathway inhibition, enhancing their therapeutic promise (Ausili et al
