nrf-2 keap 1 glutathione synthesis The Keap1-Nrf2 System: A Mediator between Oxidative Stress and Aging NRF2 Rewires Cellular Metabolism to
Description
In several disease settings, cytosolic GSTs act as anti-pyroptotic brakes by promoting or maintaining SSG on executioner or signaling nodes
For instance, the metabolism of PUFAs driven by ACSL4 increases sensitivity to ferroptosis [109], while the ACSL3-dependent metabolism of MUFAs promotes resistance to ferroptosis [110]
DkingTSpiethLBerghoffSAPiepkornLSchmidkeAMMitkovskiMet al
Han W, Pan YN, Han Z, Huang D, Hong S, Song X, Cheng L, Jiang L (2022) Advanced maternal age impairs synaptic plasticity in offspring rats
