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The pathogenesis of atopic dermatitis involves a complex interplay between skin barrier dysfunction and type 2 inflammation, among other factors 2,6-8 Dysregulated IL-4 and IL-13 signaling may exacerbate epidermal barrier dysfunction, which contributes to the clinical manifestations of disease The unique role of IL-4 in type 2 inflammation IL-4 is an orchestrator of Th2 response, creating a positive feedback loop that leads to increased secretion of IL-4, IL-13, and IL-31 9,a,b a Type 2 cytokines (such as IL-4, IL-13, and IL-31) may also be produced by other immune cells, such as ILC2

Effect of oxymatrine on liver gluconeogenesis is associated with the regulation of PEPCK and G6Pase expression and AKT phosphorylation

Overall, this review emphasize the need for comprehensive, multidisciplinary management strategies to address the complex symptomatology in cirrhosis, aiming to improve patient outcomes and quality of life

Nat Med (2000) 6:6770.10.1038/71555 24 SmithTGroomAZhuBTurskiL