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N -Trimethyllysine hydroxylase The first enzyme of the L-carnitine biosynthetic pathway is N -trimethyllysine hydroxylase, an iron and 2-oxoglutarate (2OG)-dependent oxygenase that also requires ascorbate

Support energy production and maintain energy levels

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298,311 Over-activation of glutamate-sensitive receptors in the brain can further degrade blood-brain barrier function and trigger excitotoxicity, neuroinflammation, increased oxidative stress, protein aggregation, mitochondrial dysfunction, and nerve cell death, and is considered a possible contributor to cognitive disorders, depression, reduced neuroplasticity, and neurodegenerative diseases like Alzheimer disease, Parkinson disease, multiple sclerosis, amyotrophic lateral sclerosis (ALS), and Huntington disease