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Treatment of Peyronies disease with collagenase Clostridium histolyticum and vacuum therapy: a randomized, open-label pilot study

On another hand, shikonin a polyphenol widely used in Chinese traditional medicine has shown to suppress glucose consumption and lactate production as well as inhibit the nuclear translocation and enzymatic activity of PKM2, which is responsible for stimulating the Warburg effect in macrophages, in a DSS-induced colitis mouse model (222)

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Abstract Immune cells adapt their metabolism in response to their differentiation and activation status to meet the energy demands for an appropriate immune response
