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The mechanisms of TB-500 are still being investigated, but known actions of TB4 include: Binding as an actin-binding protein to inhibit the polymerization of globular actin (G-actin) into filamentous actin (F-actin), known as actin sequestration, which results in higher G-actin levels and increased cellular motility [23, 24] TB4s ability to increase cellular motility may help progenitor cells to reach sites of injury and initiate tissue recovery [25]

gastroduodenal ulcers and bleeding, paralytic ileus), kidney damage and cardiovascular events

[PubMed: 16285944] 168

For those using oral supplements, consistency in taking them is more important than specific timing around meals