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Replicative endothelial cell senescence may lead to endothelial dysfunction by increasing the BH2/BH4 ratio induced by oxidative stress, reducing BH4 availability, and decreasing the expression of eNOS
C., Behr J., Stowasser S
It does this, in part, by interacting with the Nitric Oxide (NO) system and modulating growth factors like Vascular Endothelial Growth Factor (VEGF)
Hypertension Loss of zinc homeostasis can be both the cause and effect of hypertension
