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The rapid success of SGLT2 inhibitors reflects not only their strong mechanistic rationale but also broad applicability across HF phenotypes and the advantage of testing within large cardiovascular outcome trials originally designed for diabetes

Preclinical models as patients avatars for precision medicine in colorectal cancer: past and future challenges

While that study explored how the histone methyltransferase SETDB1 inhibits TGF--induced epithelial-mesenchymal transition (EMT) in pulmonary fibrosis via epigenetic regulation of SNAI1, our work identifies the deubiquitinase USP2 as a key mediator of TGF signaling and ferroptosis across multiple organs

Annotations: using cells as research subjects indicates in vitro