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PMC 6853408

doi: 10.1016/j.biopha.2022.113810 58 MacchioneI

Tacrolimus inhibits Ca ++ dependent activation of NFB and the nuclear factor of activated T cells (NFAT) in T lymphocytes blocking T-cell receptor-mediated lymphokine gene transcription, degranulation, exocytosis and apoptosis 31,32

The functional roles of the two GCL subunits are reviewed in this issue by Franklin et al