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These effects are largely indirect, stemming from the compounds ability to inhibit nicotinamide N-methyltransferase (NNMT) , a regulatory enzyme that consumes nicotinamide and depletes methyl donor pools (Kraus D, 2014)

Cardiomyocytes exhibit reduced mitochondrial fusion due to excessive mitochondrial division during oxygen-glucose deprivation/reoxygenation (OGD/R) (Guo 2022)

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