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The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation
For those managing a confirmed deficiency rather than simply maintaining levels, the treatment approach shifts significantly
The key distinction: an NNMT inhibitor raises NAD+ indirectly, by protecting its raw material, rather than supplying it directly the way an NMN or NR supplement does
When 5 amino 1mq inhibits NNMT in adipocytes (fat cells), it shifts these cells from a storage mode to a burning mode
