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Inhibition of system Xc - , for example by erastin, depletes intracellular cysteine and GSH [64] , thereby decreasing GPX4 activity and promoting ferroptosis

Since NAD+ declines at roughly 1%

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In fact, we observed a decrease in GABA/Gln ratio for about 60% 3 h after ischemia (3IR) in the hippocampus, then in the cortex of about 50%, and the lowest change was detected in the cerebellum, of about 25%, which correlates with the proportion of observed compromised blood flow rate in 4VO model (Pulsinelli et al