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The presence of mycotoxins in the brain can induce or serve as risk factor for the activation of the immune cells (microglial, astrocytes and endothelial cells) through the modulation of toll like receptors (TLRs), and subsequently the activation of different signaling pathways with release of inflammatory cytokines (Tumor necrosis factor- (TNF-), Interleukin-6 (Il-6), Interleukin-1 (Il-1)), nitric oxide synthase (iNOS) and chemokines