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In yeast, Ubc1 (mammalian homologous UBE2K) facilitates the formation of K48/K63-branched ubiquitin chains and regulates resistance to heat shock and DNA replication stress (Pluska et al, 2021)

Saito, T., et al.,p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

This happened because fingolimod hitched a ride by binding to the TCN2-B12 complex, facilitating their delivery to astrocytes through interactions with CD320
