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Description
Rather than interacting with receptors on the plasma membrane of their target cells, the gasotransmitters (soluble gases such as nitric oxide and carbon monoxide, as unconventional neurotransmitters) can cross the cell membrane and act directly on molecules inside the cell [36]

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As the primary tumor proliferates, neovascularization and intratumorally vascularization deteriorate, resulting in damage to the BBB

G., Springett, K., Walmsley, R., Patrick, K