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All procedures were conducted in accordance with Directive 2010/63/EU on the protection of animals used for scientific purposes

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In particular, one randomized, double-blind, placebo-controlled clinical trial demonstrated that daily oral administration of equal-lower doses (5 g/day) of l-ARG for a shorter period (1 month) compared to the current study significantly increased IIEF-6 score in 34 diabetic middle-aged men affected by mildmoderate ED of unknown etiology [27]