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Notably, immune and inflammatory mechanisms are central drivers of RV remodeling and failure

It has been used clinically in other countries (including Italy, China, and Thailand) for viral infections, hepatitis, and immune disorders for decades

The understandings of how these pathways functionally cross-talk for sustaining tumor angiogenesis during VEGF blockade is essential and perhaps may act as a basic prerequisite for designing novel therapeutic strategies to combat the growing arrogance of tumors toward anti-angiogenic agents

10.1007/BF01644188 166 RamseyB
