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The early endosome network is responsible for intracellular sorting from which the proteinligand complex can be transported via sorting tubules for exocytosis, thus completing the transcytosis

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A 2024 randomized controlled trial (RCT) with 60 women (ages 40-65) applied 0.1% GHK-Cu cream twice daily for 12 weeks, yielding 31% wrinkle reduction (visia analysis) and 28% improved skin elasticity versus placebo (Kim et al., 2024)

105, 655659 10.1111/1523-1747.ep12324134 [DOI] [PubMed] [Google Scholar] 46.Chakraborty A.K., Funasaka Y., Slominski A., Ermak G., Hwang J., Pawelek J.M.et al