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Minor shaking (brief, not vigorous) may cause limited damage, but the solution might still retain some activity

Iqbal N, Azar D, Yun YM, Ghausi O, Ix J, Fitzgerald RL

Although we expected the largest microbiome differences to occur in the lean control group relative to the obese control group, we found that the diet-switched groups exhibited a greater number of differences from the control groups than the control groups did from one another

(4) Xu R