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A study that looked at 0.5-1mg/kg/day leucovorin in patients with cerebral folate deficiency (and related neurological symptoms) found that 90% of those supplemented achieved normal 5-methyltetrahydrofolate cerebral spinal fluid concentrations

It also prevents skin damage, reverses aging, and reduces skin imperfections
McCloskey P, Balduyck B, Van Schil PE, et al

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