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doi: 10.1212/WNL.0b013e318248e50f 85 GuptaJMitraNKanetskyPADevaneyJWingMRReillyMet al
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ER depends on hepatic blood flow, uptake into the hepatocyte and enzyme metabolic capacity within the hepatocyte
Figure 1 Inflammatory cytokines such as tumor necrosis factor-alpha (TNF- ) and interleukin-6 (IL-6) play a crucial role in this process by activating serine kinases that phosphorylate insulin receptor substrates, thereby inhibiting their ability to transmit insulin signals (Amabebe et al., 2020)
