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Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial

Oral formulations have been investigated for their potential effects on the stomach, intestines, and gastrointestinal lining while also being evaluated for broader systemic activity

10.1016/0003-9861(88)90487-0 6 AmjadS.NisarS.BhatA

TB-500 (a Thymosin Beta-4 fragment) acts as a G-actin sequestering peptide affecting cytoskeletal remodelling and cell migration, with effects measured at the actin polymerization level rather than at receptor-pathway level