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This article was submitted to Predictive Toxicology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Elevated intracellular cAMP levels activate protein kinase A (PKA), which phosphorylates multiple downstream targets including transcription factors like CREB (cAMP response element-binding protein)

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