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Without understanding the individual action of BPC-159, using it in combination with BPC-157 would make it impossible to attribute any observed effects to one compound, the other, or a synergistic interaction.

Regardless of the mechanisms of cholesterol enrichment, VSMCs compared to macrophages are inefficient at lysosomal processing and trafficking of cholesterol (152,153) and express much less ABCA1(154), which all contribute to impaired cholesterol efflux (155)

However, further studies involving more extensive single-cell evaluations are essential, given the limited scope of cells analyzed in these studies (85)

Petrella F, Rizzo S, Attili I, Passaro A, Zilli T, Martucci F, et al