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Animal experiments have confirmed that PHGDH knockdown or treatment with its specific inhibitors effectively suppresses the growth of AML xenografts without significant toxicity to normal hematopoietic stem cells (95)
By contrast, a combined basic-region/first-helix substitution that disrupts both DNA binding and HLH-mediated oligomerization abolishes thermomorphogenetic output, underscoring the importance of oligomerization competence when intrinsic TAD/DBD inputs cannot be supplied by cofactors in trans
Qin C, Yang G, Yang J, Ren B, Wang H, Chen G, et al
10.1080/15548627.2018.1511263 99 YuZ
