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Excipients Sodium chloride BP Sodium acetate USP Sodium Methyl Hydroxybenzoate BP Sodium Propyl Hydroxybenzoate BP Glacial acetic acid / Sodium acetate BP (for pH adjustment) Water for Injections BP Incompatibilities None known

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For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

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