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French physician Michel Pistor developed the technique in 1952, and it has been refined over decades of clinical use in aesthetic medicine worldwide

While research on this specific effect is still limited, some evidence suggests that Glutathione may contribute to skin brightening through several mechanisms

The KD was also shown to increase anti-inflammatory responses in glaucomatous mice, evidenced by increased expression of Arginase 1, a marker of neuroprotective anti-inflammatory microglia, as well as increased expression of the anti-inflammatory cytokine IL-4 in retinas and optic nerves (40)

Bee venom and melittin disrupt renal cell redox homeostasis by inhibiting -MG uptake through a PLA2-oxidative stress-Ca2+ pathway ( 2 activation, Ca2+, and oxidative stress in renal cells ( Disseminated intravascular coagulation (DIC) with associated thrombocytopenia presents another potential mechanism for kidney injury