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Abnormal autophagy and endoplasmic reticulum (ER) damage, which compromise RGC viability due to intracellular accumulation of misfolded proteins, loss of calcium homeostasis and deficient protein trafficking (73) represent additional early features of pressure-related RGC stress, whereas axonal constriction constitutes both a possible early insult and potential coup de grce that instigates apoptosis
No significant results were observed with relation to serum folate levels in this study
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