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To further investigate the role of REST in AKI, both IRI- and cisplatin-induced AKI mouse models were established (Supplemental Figure 2, AF)

For this reason, targeting each component of humoral response such as alloantibody, B cells, or PC, would tentatively reduce the steady state level of DSA, this would not promote long-term control of humoral response after transplantation

Macrophages form erythropoietic niches and regulate iron homeostasis to adapt erythropoiesis in response to infections and inflammation
Notably, antioxidant defense-related proteins are upregulated over time, reducing ROS accumulation and preventing cellular deterioration (Yang et al
