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A double-blind randomized trial of adjunctive N-acetylcysteine, a precursor of glutathione, in individuals with bipolar depression yielded positive results compared to placebo [98, 99]

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In human hematopoietic cell lines, phosphorylation of H3Y41 by Janus kinase 2 (JAK2) destabilizes binding of HP1a to histone H3 (Dawson et al
