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Description
Following either local secretion or systemic circulation to target tissues, IGF-1 primarily exerts its biological effects through binding to the IGF-1 receptor (IGF-1R), with minimal interaction occurring through the insulin receptor (IR) (Figure 2) (Werner, 2023)
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CRP binding to oxLDL and apoptotic cells occurs through phosphorylcholine, and binding to this ligand starts phagocytosis (100, 170, 175181)

if the overdose is spread over a period of time the threshold may be higher, as the initial paracetamol dose is effectively metabolized

The molecule carries an -aminoisobutyric acid (Aib) substitution at position 2 that blocks DPP-IV cleavage, conferring complete resistance to the proteolytic step that inactivates native incretins within minutes
