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doi: 10.1126/scitranslmed.3005727 230 KapsogeorgouEKChristodoulouMIPanagiotakosDBPaikosSTassidouATzioufasAGet al

Unreconstituted retatrutide stored properly can maintain stability for months or even years, far longer than any reconstituted solution

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For instance, surface modification with Tet-1 peptide facilitates blood-brain barrier penetration for glioblastoma and Alzheimers therapy, while PLGA-TPGS (d--tocopheryl polyethylene glycol succinate) nanoparticles exhibit preferential accumulation in hepatocellular carcinoma (HepG2) cells, significantly improving antitumor efficacy and reducing systemic toxicity in vivo [98, 99]